Are Omega-3 fatty acids effective in treating heart diseases?
The Synthesis of Omega-3 fatty Acid involves the Na-channel which is a membrane protein that conducts Na-ions through a cell’s plasma membrane. Depending on the trigger that opens the Na-channel, it’s called voltage gated (when the channel opens because of a voltage-change) or ligand gated (when the binding of a ligand opens the channel). The Na-channel mediates fast depolarization and conduct electrical impulses throughout nerve, muscle and heart, thereby enabling co-ordination of higher processes ranging from locomotion to cognition.
Docosahexaenoic acid (Omega-3)(DHA) suppresses the activity of Na-channels. That’s the main reason why Omega 3 lowers the heart rate and causes many of the beneficial effects. Clinical and experimental data indicate that changes in the expression of voltage-gated sodium channels play a key role in the pathogenesis of neuropathic pain and that drugs that block these channels are potentially therapeutic. Clinical and experimental data also suggest that changes in voltage-gated sodium channels may play a role in inflammatory pain, and here too sodium-channel blockers may have therapeutic potential.
Omega-3 (DHA) fatty acids are considered to contain essential nutrients in preventing and managing heart disease
Omega-3 fish oil contains both docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Omega-3 fatty acids are essential nutrients that are important in preventing and managing heart disease.
Findings show omega-3 fatty acids may help to:
- Lower blood pressure
- Reduce triglycerides
- Slow the development of plaque in the arteries
- Reduce the chance of abnormal heart rhythm
- Reduce the likelihood of heart attack and stroke
- Lessen the chance of sudden cardiac death in people with heart disease
The American Heart Association (AHA) recommends that everyone eats fish (particularly fatty, coldwater fish) at least twice a week. Salmon, mackerel, herring, sardines, lake trout, and tuna are especially high in omega-3 fatty acids. While foods are your best bet for getting omega-3s in your diet, fish oil supplements are also available for those who do not like fish. The heart-healthy benefits of regular doses of fish oil supplements are unclear, so talk to your doctor to see if they’re right for you. If you have heart disease or high triglyceride levels, you may need even more omega-3 fatty acids. Ask your doctor if you should take higher doses of fish oil supplements to get the omega-3s you need.
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